Background: Quality of life (QoL) is increasingly recognized as central to the broad construct of recovery in\npatients with substance use disorders (SUD). However, few longitudinal studies have evaluated changes in QoL\nafter SUD treatment and included patients with SUD that were compulsorily hospitalized. This study aimed to\ndescribe QoL among in-patients admitted either voluntarily or compulsorily to hospitalization and to examine\npatterns and predictors of QoL at admission and at 6 months post treatment.\nMethods: This prospective study followed 202 hospitalized patients with SUD that were admitted voluntarily\n(N=137) or compulsorily (N=65). A generic QoL questionnaire (QoL-5) was used to assess QoL domains.\nRegression analysis was conducted to identify associations with QoL at baseline and to examine predictors of\nchange in QoL at a 6-month follow-up.\nResults: The majority of patients had seriously impaired QoL. Low QoL at baseline was associated with a high\npsychiatric symptom burden. Fifty-eight percent of patients experienced a positive QoL change at follow-up. Although\nthe improvement in QoL was significant, it was considered modest (a mean 0.06 improvement in QoL-5 scores at\nfollow-up; 95% confidence interval: 0.03 - 0.09; p<0.001). Patients admitted voluntarily and compulsorily showed QoL\nimprovements of similar magnitude. Female gender was associated with a large, clinically relevant improvement in\nQoL at follow-up.\nConclusions: In-patient SUD treatment improved QoL at six month follow-up. These findings showed that QoL\nmeasurements were useful for providing evidence of therapeutic benefit in the SUD field.
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